Polymorphisms of the Vitamin D Receptor Gene in Crohn’s Disease

Abstract Introduction Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory conditions of the gastrointestinal tract. Studies have shown that polymorphisms vitamin D receptor (VDR) gene may help elucidate pathogenesis CD. Objectives To analyze role VDR (ApaI, BsmI, FokI, TaqI) in development Methods The present study is a systematic review with meta-analysis. total 50 articles English Portuguese published from 2000 to 2020 were selected 3 databases. relationship between CD was addressed 16 articles. Results TaqI polymorphism analyzed 3,689 patients 4,645 control subjects (odds ratio [OR] = 0.948; 95% confidence interval [95%CI] 0.851–1.056; p 0.3467). ApaI studied 3,406 4,415 (OR 1,033; 95%CI 0.854–1.250; 0.7356). For FokI polymorphism, there 2,998 4,146 0.965; 0.734–1.267; 0.7958). Lastly, BsmI 2,981 4,477 1,272; 0.748–2.161; 0.3743). Conclusion These four not associated Therefore, further studies larger samples required corroborate or rectify conclusions